The three original strains are Og Kush, White Widow and Grand Daddy Purp. Lil Wyte used three strains of marijuana to create his own strain of medical cannabis called OG WYTE Kush. Lil Wyte passed up the opportunity of writing the song ' It's Hard out Here for a Pimp', because he could not relate to the lyrics of having more than one woman. He has been described as a rapid lyricist. The album had three popular songs: 'Oxycotton', 'My Smoking Song', and 'Acid'. The album Doubt Me Now featured Juvenile, Three 6 Mafia, Frayser Boy, La Chat and Josey Scott. His debut album Doubt Me Now was released in 2003 and it became popular, selling over 135,000 copies without promotion. Lil Wyte appeared on Project Pat's song 'Crash da Club' from his album Layin' da Smack Down in 2002. Three 6 Mafia signed the rapper and worked later with his debut album. Juicy J and DJ Paul (one song in particular is said to have gotten him signed, a song titled Memphiz Playaz). The group's home-made demo tape came to the attention of Three 6 Mafia. Lil Wyte was part of a local rap group, the Shelby Forest Click. Lanshaw dropped out of high school, but eventually earned his high school diploma.

Lanshaw rapped with his friend 'Lil Black', who inspired him to use the pseudonym 'Lil Wyte' and write songs instead of freestyling. He participated in freestyle battles at high school when he was in ninth grade. Growing up in Frayser, Lil Wyte discovered his rapping talent at a young age as he could rap Sir Mix-a-Lot's entire song ' Baby Got Back' completely.

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